Table 3.
Multivariable-adjusted Cox proportional hazards models for arginine derivatives associated with incident AF on the left and result from stepwise selection on the right side
Variable | Hazard Ratio | 95% CI | P Value | |
---|---|---|---|---|
ADMA | 1.10 | 0.79 | 1.52 | 0.58 |
L-arginine | 1.06 | 0.73 | 1.55 | 0.76 |
SDMA | 0.96 | 0.83 | 1.11 | 0.56 |
L-arginine/ADMA | 1.02 | 0.65 | 1.59 | 0.94 |
B-type natriuretic peptide | 1.23 | 1.15 | 1.31 | <0.0001 |
C-reactive protein | 1.06 | 0.96 | 1.18 | 0.24 |
eGFR | 1.12 | 0.98 | 1.28 | 0.10 |
Hazard ratios are per one standard deviation increase in loge-biomarker concentration. Models included all biomarkers simultaneously and adjusted for age, sex, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, diabetes, hypertension treatment, myocardial infarction, and heart failure simultaneously.
CI denotes confidence interval; eGFR denotes estimated glomerular filtration rate.