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. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Biochim Biophys Acta. 2016 Apr 19;1862(7):1324–1336. doi: 10.1016/j.bbadis.2016.04.011

Table 1.

Genotypic differences in CD11c on Cln3^−/− and wild type leukocytes from spleen and blood samples as assessed by flow cytometry.

Variable	Wild type		Cln3^−/−

	Mean	SD	Mean	SD	P value
Spleen
CD11c^hi MFI on F480+ macrophages	76160.00	1864.94	72000.000	2815.138	0.073
CD11c^hi MFI on F480+ macrophages	0	0	72000.000	2815.138	0.073
CD11c^low MFI on F480+ macrophages	19320.00	248.998	21020.000	426.615	<.0001
CD11c^low MFI on F480+ macrophages	0	248.998	21020.000	426.615	<.0001
CD11c^hi MFI	53280.00	6488.20	55680.000	3343.900	0.929
	0	0	55680.000	3343.900	0.929
CD11c^low MFI	11080.00	258.800	11860.000	391.200	0.023
	0	258.800	11860.000	391.200	0.023
%CD11c^hi of CD11c+	14.480	3.238	21.620	2.759	0.033
%CD11c^low of CD11c+	85.500	3.160	78.300	2.723	0.033
Blood
CD11c MFI on CD14+ monocytes	11600.00	374.166	15366.667	2361.920	0.029
CD11c MFI on CD14+ monocytes	0	374.166	15366.667	2361.920	0.029
CD11c^hi MFI	10340.00	364.692	14250.000	2375.500	0.050
CD11c^hi MFI	0	364.692	14250.000	2375.500	0.050
CD11c^low MFI	3035.400	51.432	2760.167	124.857	0.013
%CD11c^hi of CD11c+	50.340	2.606	57.217	2.460	0.007
%CD11c^low of CD11c+	49.700	2.639	42.783	2.431	0.007

Significant results in bold. MFI = median fluorescence intensity. SD = standard deviation.

Mean defined as average MFI or average percent of positively gated cells within each genotype.