Table 3.
Statistical comparison of mean analyte concentrations in 24 hour medium from Cln3−/− and wild type bone marrow macrophages stimulated with lipopolysaccharide as assessed with Luminex assay.
| Analyte | Wild Type | Cln3−/− | P value | ||
|---|---|---|---|---|---|
|
| |||||
| Concentration (pg/ml) | Concentration (pg/ml) | ||||
|
| |||||
| Mean | SD | Mean | SD | ||
| G-CSF | 846.600 | 808.141 | 1592.000 | 972.391 | 0.994 |
| IFN-γ | 12.078 | 1.507 | 7.074 | 0.984 | 0.005 |
| IL-1α | 1130.400 | 103.106 | 786.000 | 112.927 | 0.020* |
| IL-1β | 2474.800 | 475.035 | 931.800 | 88.220 | 0.002 |
| IL-2 | 10.322 | 4.300 | 5.080 | 1.914 | 0.534 |
| IL-5 | 25.310 | 4.097 | 24.158 | 1.976 | 1.000 |
| IL-6 | 2268.010 | 1963.369 | 2689.000 | 2045.084 | 1.000 |
| IL-7 | 3.796 | 1.425 | 1.836 | 0.463 | 0.321 |
| IL-10 | 1720.400 | 352.180 | 974.000 | 113.475 | 0.039 |
| IL-13 | 13.270 | 18.994 | 71.830 | 68.706 | 0.888 |
| IL-15 | 173.000 | 24.607 | 130.000 | 9.000 | 0.119 |
| IL-17 | 4.382 | 0.575 | 1.444 | 0.243 | <.0001 |
| IP-10 | 269.630 | 261.456 | 84.990 | 73.487 | 0.974 |
| KC | 8011.600 | 372.679 | 6174.600 | 1500.536 | 0.444 |
| MCP-1 | 1186.800 | 132.006 | 1512.000 | 298.268 | 0.687 |
| MIP-1α | 5408.800 | 878.988 | 4969.600 | 154.165 | 0.999 |
| RANTES | 2559.400 | 1974.671 | 945.200 | 337.517 | 0.901 |
| TNF-α | 1824.000 | 505.860 | 1443.800 | 668.982 | 1.000 |
| IL-12p70 | 78.174 | 5.338 | 61.392 | 4.937 | 0.017 |
| IL-9 | 243.000 | 41.641 | 134.800 | 13.349 | 0.011 |
*
not significant after type I correction. Significant results in bold. P values are Dunn-Sidak adjusted. n=5 per genotype. SD = standard deviation. Mean defined as average analyte concentration (pg/ml).