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. Author manuscript; available in PMC: 2016 Jun 9.
Published in final edited form as: Brain Res. 2015 Mar 11;1628(Pt A):199–209. doi: 10.1016/j.brainres.2015.02.053

Fig. 2.

Fig. 2

The effects of FP1 continuous theta burst stimulation (cTBS) on TMS-evoked brain activity. In this pilot study, interleaved TMS/BOLD imaging was used to measure TMS-evoked BOLD signal immediately before and after cocaine users were given a dose of cTBS to the left frontal pole (A). The TMS coil was placed over FP1 (EEG:10–20 system) for both the Interleaved TMS/BOLD scan (left & right panel) and the cTBS session (center panel). The red area represents the region of interest to which the coil is targeted (AAL: left superior and middle orbital prefrontal cortex inferior to the anterior commisure). Real cTBS (LTD-like) led to a significant decrease in BOLD signal in the left orbital/medial prefrontal cortex and ventral striatum (SPM8, p<0.05 Family Wise Error correction, negative Z-scores shown). The cTBS protocol was 2 trains of 1800 pulses, 110% RMT, 60 s intertrain interval., intensity ramped from 80–110% over first 30 s. L=left hemisphere.

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