Table 3.
The effect of medial prefrontal cortex cTBS treatment (LTD-like) on the BOLD response to medial prefrontal cortex stimulation (MPFC). The statistical contrasts in the table include: (A) real TMS: after treatment<before treatment, (B) real TMS: after treatment>before treatment, (C) [(real TMS: after<before)- (Sham TMS: after<before)].
| Cluster Statistics
|
MNI coordinates
|
Regions (including Harvard-Oxford Labels) | ||||
|---|---|---|---|---|---|---|
| size | p(unc) | Z | x | y | z | |
| (A) Real cTBS: Areas with lower BOLD signal after MPFC cTBS | ||||||
| 124 | 0.001 | 3.97 | 0 | 8 | −5 | Medial prefrontal cortex, cingulate, subcallosal (14%) |
| 3.76 | −9 | 8 | −8 | Left nucleus accumbens (93%) | ||
| 3.55 | −30 | 32 | −17 | Left orbital frontal cortex (58%) | ||
| (B) Real cTBS: Areas with higher BOLD signal after MPFC cTBS | ||||||
| 190 | 0 | 3.88 | 21 | −52 | 37 | Precuneus |
| 3.77 | 12 | −49 | 52 | Precuneus (52%) | ||
| 3.74 | 33 | −43 | 52 | Superior parietal (46%) | ||
| 97 | 0.002 | 3.22 | 57 | 2 | 28 | Right dorsolateral Prefrontal, Precentral gyrus (42%) |
| 3.18 | 33 | 17 | 13 | Frontal operculum (49%) | ||
| 3.07 | 48 | 8 | 16 | Right inferiorfrontal gyrus (27%) | ||
| (C) Real cTBS versus sham cTBS: areas with lower BOLD signal after cTBS | ||||||
| 128 | 0.001 | 4.07 | −57 | −46 | −5 | Left insula, middle temporal gyrus (31%) |
| 3.97 | −66 | −52 | 1 | Left middle temporal gyrus (62%) | ||
| 97 | 0.014 | 3.44 | −15 | −19 | 13 | Left thalamus, caudate |