Table 3. Body weight in mice with subacute EtOH-induced intoxication.
Groups | Body weights (g) | Weight gains | Liver weight | |||
---|---|---|---|---|---|---|
Day - 1 | Day 0 [A]* | Day 14 [B]* | [B-A] | absolute | relative | |
Controls | ||||||
Intact | 21.96±1.58 | 19.86±1.73 | 23.21±2.04 | 3.35±0.87 | 0.881±0.095 | 3.801±0.351 |
EtOH | 21.99±1.47 | 19.83±1.50 | 17.98±0.82a | - 1.85±0.94a | 0.478±0.038a | 2.661±0.207a |
Silymarin | 21.90±1.81 | 19.85±1.74 | 20.65±1.32ab | 0.80±0.51ab | 0.669±0.038ab | 3.246±0.196ab |
HSCF treated | ||||||
500 mg/kg | 21.96±1.69 | 19.88±1.86 | 20.66±1.98ab | 0.79±0.51ab | 0.665±0.047ab | 3.243±0.364ab |
250 mg/kg | 22.05±1.54 | 20.01±1.68 | 20.31±1.54ab | 0.30±0.38ab | 0.623±0.036ab | 3.076±0.218ab |
125 mg/kg | 21.99±1.47 | 20.03±1.40 | 19.93±1.48ac | - 0.10±0.86ac | 0.594±0.027ab | 2.995±0.240ac |
Values are expressed as Means ± SD of eight mice
*All animals were overnight fasted. Day 0 means the day of first test substance administration. Day 14 means 24 hrs after the last (14th) test substance administration
a p<0.01 as compared with intact control by LSD test. b p<0.01 and c p<0.05 as compared with EtOH control by LSD test. EtOH, Ethanol; HSCF, Hoveniae Semen Cum Fructus extracts