Table 5. Hepatic TG and TNF-α contents with hepatic CYP450 2E1 activity in subacute EtOH-treated mice.
Groups | Hepatic contents | Hepatic CYP450 2E1 activity (4-nitrocatechol μM/min/mg protein) |
|
---|---|---|---|
TG (mg/g tissue) | TNF-α (pg/mg protein) | ||
Controls | |||
Intact | 18.94±3.51 | 27.70±15.99 | 1.91±0.49 |
EtOH | 136.74±21.06a | 90.46±17.04a | 8.03±1.55a |
Silymarin | 79.93±16.24ab | 52.81±13.12ab | 4.40±1.49ab |
HSCF treated | |||
500 mg/kg | 81.19±17.88ab | 53.63±12.32ab | 4.45±1.10ab |
250 mg/kg | 98.73±15.49ab | 61.89±17.33ab | 5.34±0.88ab |
125 mg/kg | 110.26±17.64ab | 67.60±13.40ab | 6.06±0.97ab |
Values are expressed means ±SD of ten mice.
a p<0.01 as compared with intact control mice by LSD test. b p<0.01 as compared with EtOH control mice by LSD test. EtOH, Ethanol; HSCF, Hoveniae Semen Cum Fructus extracts; CY, Cytochrome; TG, Triglyceride;TNF, Tumor necrosis factor.