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Sensitivity and specificity of HRM analysis in comparison with Drug susceptibility
| Drug | Target | HRM profile | % variant | Drug susceptibility | % resistant | Sensitivity (%) | Specificity (%) | ||
|---|---|---|---|---|---|---|---|---|---|
| + | − | + | − | ||||||
| Rifampicin | rpoB | 79 | 88 | 47.3 | 78 | 89 | 46.7 | 98.7 (92.2–99.9) | 97.75 (91.2–99.6) |
| Isoniazid | katG and/or | 77 | 90 | 46.1 | 78 | 89 | 46.7 | 98.7 (92.2–99.9) | 100 (94.2–99.9) |
| inhA promoter | |||||||||
