Fig. 4.

Increase of cross-clades anti-Tat Abs elicited in vaccinees. a Baseline OD values of anti-Tat IgM, IgG and IgA against clades C, D and A in vaccinees prior to immunization (n = 29, 76 % C clade, 41 % A clade, 14 % D clade). b Changes from baseline of IgM, IgG and IgA Ab responses (OD) against Tat from other clades (C, D, A) after vaccination. Testing was performed at the peak of Ab responses (between 12 and 24 weeks). Statistical analysis was performed using the Wilcoxon signed-rank test. p values assess the increase from baseline