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TLR4 deficiency reduces the extent of macrophage infiltration and MCP-1 secretion. (A) Quantitative analysis of macrophage immunoreactivity in aortic sinus plaques of Apoe–/–/TLR4–/– and Apoe–/–/TLR4+/+ mice, expressed as a proportion of the total plaque areas (n = 7 per group). Means and SD are shown (*, P < 0.01). (B) MCP-1 serum concentrations of Apoe–/–/TLR4–/– and Apoe–/–/TLR4+/+ mice (n = 8 for Apoe–/–/TLR4+/+ and n = 14 for Apoe–/–/TLR4–/–). Means and SD are shown (*, P < 0.01).
