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. 2009 Jul 15;23(14):1613–1618. doi: 10.1101/gad.1826409

Figure 1.

Figure 1.

MEN regulation. (A) An unperturbed mitosis. Bub2 Bfa1 and Tem1 are associated with the dSPB, and Kin4 is associated with the mSPB and the mother cell cortex. The mother cell keeps Tem1 in the GDP (off) state. Lte1 is localized to the cortex of the bud and is kept there by the septins. Mitosis places the dSPB in the vicinity of Lte1, and Tem1 is activated. (B) Misaligned spindle. The asymmetry of regulators is lost and Kin4 is associated with both SPBs, which keeps Tem1 in the GDP (off) state and inhibits MEN activation.