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HER2, P53, and Ki67 overexpression in osteosarcoma. (a) Photomicrograph of osteosarcoma (hematoxylin and eosin). Immunohistochemical analysis revealed (b) Ki67 with 30% positivity, and (c) HER2 grade 3+ reactivity. (d) P53 demonstrating clusters of nuclei positivity of neoplastic cells
