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Effect of coexistence of HER2 overexpression and p53 protein accumulation on (a) disease-free and (b) overall survival among 56 patients with osteosarcoma. Free and overall survival were significantly worse in patients with HER2 and p53-positive tumors than in patients with HER2 and p53-negative tumors and HER2 or p53 positive tumors (P = 0.01 for both)
