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Stereological analysis of reduced number of TH-positive LC neurons in parkin null mice. (A) Number of TH-positive and Nissl-positive neurons in the SNpc of aged (12- and 18-month-old) WT and parkin KO mice. (B) Number of TH-positive LC neurons in young (2-month-old) and aged (12- and 18-month-old) parkin null mice and age-matched controls. Data are expressed as mean ± SEM. *, P < 0.05, analyzed by two-tailed t test.
