Table 3. Haplotype analysis of paternally inherited alleles in maternal plasma.

	Genotype for SNP rs2187610		Paternal haplotype analysis†		Maternal plasma SABER analysis
Case	Mother	Father	HBB mutant allele	HBB wild-type allele	SNP G allele	Paternal HBB mutation	Fetal HBB genotype‡
3	CC	GC	G	C	Neg	Neg	*/*
11	CC	GC	G	C	Pos	Pos	F/*
12	CC	GC	G	C	Neg	N.A.	*/*

Neg, negative; Pos, positive; N.A., not applicable.

^†G and C denote the rs2187610 allele linked to the mutant or wild-type paternal HBB alleles, respectively

^‡The fetal genotype determined by conventional methods is indicated by the inheritance of the paternal mutation F, the maternal mutation M, or the normal allele, *