FIG. 1.

IUL TCDD exposure causes urinary dysfunction in male mice exposed in adulthood to T+E₂. Male mice were exposed to TCDD (a single 1 μg/kg maternal dose on 13 dpc) or corn oil (vehicle control), implanted sc with compressed testosterone (T) and 17β−estradiol (E₂) pellets at 8 wk of age, and analyzed 4–18 wk later. (A) Lower urinary tracts from representative mice are shown. (B) Relative bladder weight is increased by IUL TCDD exposure in T+E₂ treated mice. Results are mean ± SE, n ≥ 13/group. The asterisk indicates a significant difference (P < .05) between groups. Abbreviations: IUL: In utero and lactational; TCDD, tetrachlorodibenzo-p-dioxin; SV: seminal vesicle. Color image is available in the online version of the article.