FIG. 4.

IUL TCDD exposure changes collagen fiber distribution in the lower urinary tract in mice exposed as adults to T+E₂. Picrosirius red stained-sections of anterior (AP), ventral (VP), and dorsolateral (DLP) prostates, seminal vesicles (SV) and bladders of corn oil + T+E₂- and TCDD + T+E₂-exposed mice were imaged under polarized light and red, orange, yellow, and green pixel densities were quantified. Results in the “Total” column combined data from all mice receiving 4–18 wk T+E₂ exposure, while the “Subchronic” column includes only mice with 6–12 wk T+E₂ exposure, and the “Chronic” column includes mice with 16–18 wk T+E₂ exposure. Results are mean ± SE of at least 5 mice. An asterisk indicates a significant difference (P < .05) between groups.