FIG. 5.
IUL TCDD exposure increases relative kidney wet weight and hydronephrosis incidence in mice exposed in adulthood to T+E2. A, Representative kidneys collected from corn oil + T+E2- and TCDD + T+E2-exposed mice. Frank hydronephrosis is characterized by renal cysts and dilation of the renal pelvis and calyces, exists in the TCDD-exposed kidney. B, Relative kidney (left and right) wet weights from IUL TCDD-exposed + T+E2-treated mice compared to corn oil + T+E2 controls. Results are mean ± SE from 9-17 mice per treatment group. C, In IUL TCDD-exposed + T+E2-treated mice, the incidence of hydronephrosis was significantly higher compared to corn oil + T+E2 controls. An asterisk indicates a significant difference (P < .05) between groups. Color image is available in the online version of the article.