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. 2016 Feb 10;151(1):88–103. doi: 10.1093/toxsci/kfw026

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Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US.

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FIG. 6 — Effect of the number of genes in the biomarker on prediction of ERα modulation. A, Comparison of predictions of ERα activation across 327 biosets in the MCF-7 compendium using the original ERα biomarker and shortened versions (illustrated in inset). The bioset predictions were rank-ordered based on the −log(P value) derived using the full-length biomarker. Linear trend lines were added to illustrate the intersection with −log(P value) = 4. B, Relationships between the length of the biomarker and percentage of biosets falsely predicted to be negative for activation or suppression.