Table 1.

Sleeping Beauty (SB) based screens for cancer genes in vivo published to date. Beginning with the oldest papers, the first author, year of publication and title are shown as well as primary tissue/cancer type targeted in the work. References [9••,10••,11••,13••,14,16•,17,18,19•,20,21,23,27–47]

Author/year	Year	Cancer Type	Title
Dupuy et al.,	2005	Blood	Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.
Collier et al.,	2009	Blood	Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.
Keng et al.,	2009	Liver	A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
Starr et al.,	2009	Colorectal	A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.
Berquam-Vrieze et al.,	2011	Blood	Cell of origin strongly influences genetic selection in a mouse model of T-ALL.
Collier et al.,	2011	Sarcoma	Cancer gene discovery in solid tumors using transposon-based somatic mutagenesis in the mouse.
Karreth et al.,	2011	Skin	In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF- induced mouse model of melanoma.
Koudijs et al.,	2011	Blood	High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors.
March et al.,	2011	Colorectal	Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.
Starr et al.,	2011	Colorectal	A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.
van der Weyden et al.,	2011	Blood	Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.
Keng et al.,	2012	Liver	Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR.
Koso et al.,	2012	Nervous system	Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells.
Mann et al.,	2012	Pancreas	Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.
O’Donnell et al.,	2012	Liver	A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/ Src-2 in liver cancer.
Pérez-Mancera et al.,	2012	Pancreas	The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
van der Weyden et al.,	2012	Blood	Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1.
Wu et al.,	2012	Nervous system	Clonal selection drives genetic divergence of metastatic medulloblastoma.
Genovesi et al.,	2013	Nervous system	Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.
Lastowska et al.,	2013	Nervous system	Identification of a neuronal transcription factor network involved in medulloblastoma development.
Quintana et al.,	2013	Skin	A transposon-based analysis of gene mutations related to skin cancer development.
Rahrmann et al.,	2013	Nervous system	Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.
Tang et al.,	2013	Blood	Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
van der Weyden et al.,	2013	Blood	Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity.
Zanesi et al.,	2013	Blood	A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model.
Rogers et al.,	2013	Mixed	Adaptive immunity does not strongly suppress spontaneous tumors in a Sleeping Beauty model of cancer.
Bard-Chapeau et al.,	2014	Liver	Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.
Been et al.,	2014	Sarcoma	Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice.
Vyazunova et al.,	2014	Nervous system	Sleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis
Koso et al.,	2014	Nervous system	Identification of FoxR2 as an oncogene in medulloblastoma.
Takeda et al.,	2015	Colorectal	Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.
Perna et al.,	2015	Skin	BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.
Mann et al.,	2015	Skin	Transposon mutagenesis identifies genetic drivers of BrafV600E melanoma.
Moriarity et al.,	2015	Bone	A Sleeping Beauty Forward Genetic Screen Identifies New Genes and Pathways driving Osteosarcoma Development and Metastasis.

Sleeping Beauty mouse Models Identify Candidate Genes Involved in Gliomagenesis, PLoS One 2014 (Pubmed ID: 25423036).