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. 2004 Jul 12;101(29):10827–10832. doi: 10.1073/pnas.0402141101

Fig. 2.

Fig. 2.

Behavioral effects of BDNF KO from adult brain. (A) Locomotor activity in the BDNF adult KO mice (n = 26) was indistinguishable from genotype controls maintained on dox (adult CTL; n = 21). Locomotor activity was assessed over a 10-min period, and the number of photocell beam breaks was recorded. (B and C) Adult KO mice (n = 16) do not display altered levels of aggression in the resident intruder paradigm compared with adult CTLs (n = 13). (D) Context-dependent fear conditioning is decreased in adult KO mice (n = 26) 24 h after training compared with adult CTL mice (*, P < 0.05; n = 22). The deficit in context-dependent fear conditioning persists on repeat testing 7 days after training (*, P < 0.05). No significant difference was observed in baseline freezing behavior. Cue-dependent fear conditioning was indistinguishable in inducible BDNF adult KO and adult CTL mice.