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. 2004 Jul 12;101(29):10827–10832. doi: 10.1073/pnas.0402141101

Fig. 3.

Fig. 3.

BDNF modulates LTP of the CA3 to CA1 inputs in adult hippocampus. (A–F) Traces show fEPSPs recorded in the stratum radiatum before (Left) and after (Right) two independent CA3 to CA1 inputs are stimulated according to the protocol indicated (Center). Stimulus intensities of 0% (A and D), 40% (B and E), or 100% (C and F) of the theta burst stimulation (TBS) intensity to induce a maximal fEPSP were used. Baseline amplitude of the slope of the fEPSP evoked by input 2 was established over 10 min; then the paired stimuli were applied and the fEPSP slope was monitored for 130 min (G and H). With a 40% stimulus intensity, the average control fEPSP was enhanced over the recording period by >150% in control (n = 9), but the BDNF KO (n = 9) slices showed no enhancement (G). At 100% stimulus intensity, control showed >170% enhancement and the BDNF KO slices showed an enhancement of ≈140% (H).