Fig. 5.

Behavioral response of CTL and BDNF KO mice in the forced swim test to subchronic antidepressant treatment. Animals were administered saline or desipramine 24, 4, and 1 h before the swim test (10 mg/kg i.p., 10 mg/kg i.p., and 20 mg/kg s.c., respectively). Saline-treated control (n = 10) and BDNF KO (n = 10) mice exhibited similar immobility times. Subchronic desipramine treatment significantly reduced immobility time in the control mice (n = 10) but not in the BDNF KO mice (n = 10). Results are presented as mean immobility (sec) ± SEM; ANOVA and post hoc Tukey's test revealed a significance of P < 0.05 (asterisks) for saline control versus desipramine control [F_{(1, 57)} = 8.51; P < 0.01].