TABLE 2.
Bone Strength Determination in Femur and Vertebrae of Pb-Treated 6-Month-Old Female Mice.
|
3-pt bending |
Stiffness (N/mm) | Max load (N) | Energy to failure (mJ) | Post-yield energy (mJ) |
|---|---|---|---|---|
| 0 ppm Pb | 119.91 ± 2.91 | 15.62 ± 0.11 | 2.68 ± 0.18 | 1.91 ± 0.18 |
| 200 ppm Pb | 127.22 ± 5.00 | 15.09 ± 0.28 | 2.12 ± 0.21 | 1.31 ± 0.31 |
| 500 ppm Pb | 138.57 ± 3.86*,** | 16.36 ± 0.21*,** | 4.28 ± 0.27*,** | 3.54 ± 0.28*,** |
| Compression | ||||
| 0 ppm Pb | 131.28 ± 5.03 | 16.53 ± 0.21 | 4.18 ± 0.23 | 4.19 ± 0.35 |
| 200 ppm Pb | 113.22 ± 5.09** | 15.60 ± 0.37 | 3.11 ± 0.28** | 1.96 ± 0.24** |
| 500 ppm Pb | 106.23 ± 3.35*,** | 14.15 ± 0.15*,** | 3.20 ± 0.19* | 3.69 ± 0.44* |
Flexure testing was applied to mouse femurs and compression testing to LV4. Resistance to force was plotted over time and data was calculated to represent mean ± SEM for 7 mice/group, *P < .05 for effect of Pb, **P < .05 for multiple comparisons versus 0 Pb.