FIG. 6.

Metabolic reprogramming for NADPH production. Integration of transcriptomic, hepatic and serum metabolomic, and KEGG pathway data for (A) the PPP, and (B) serine and folate metabolism. The color scale represents the log₂(fold-change) for genes and metabolites. Yellow identifies converging metabolites and gray indicates metabolites not measured or detected. Genes are identified as rectangles and metabolites as circles. The upper left corner provides the maximum AhR enrichment fold-change and upper right corner indicates the highest pDRE MSS. Circles contain the P-value for detected metabolites. An expandable and interactive version that provides additional complementary information can be viewed at http://dbzach.fst.msu.edu/index.php/supplementarydata.html. C, Expression of hepatic Phgdh was confirmed by QRTPCR. Bars represent mean + SEM (n = 5). Asterisks (*) indicates P ≤ .05 compared with vehicle determined by 1-way ANOVA followed by Dunnett’s post hoc test.