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Dose- and time-dependent Cdkn1a expression. A, Dose-dependent hepatic Cdkn1a mRNA expression following gavage every 4 days for 28 days, and (B) time-dependent expression following a single bolus dose of 30 µg/kg TCDD. Bars represent mean + SEM (n = 4–5). Asterisks (*) indicate P ≤ 0.05 compared with vehicle determined by 1-way ANOVA followed by Dunnett’s post hoc test or 2-way ANOVA following by Tukey’s post hoc test.
