Table 5.
Sensitivity Analysis Values
| Parameter | Base case value | Lower range | Upper range |
|---|---|---|---|
| Sensitivity of co-testing | 82% | 76.2% | 85% |
| Specificity of co-testing | 85.3% | 81.5% | 88.7% |
| Sensitivity of HPV primary | 72% | 67.8% | 76.2% |
| Specificity of HPV primary | 85.2% | 81.5% | 88.7% |
| Five-year survival for ICC (HPV primary)* | 85% | — | 90% |
| Cost of colposcopy biopsy | $304.78 | $274.30 | $335.26 |
| Cost of HPV genotyping | $43.58 | $39.22 | $47.94 |
| Cost of HPV pooled testing | $43.58 | $39.22 | $47.94 |
| Cost of ICC incremental | $1,597 | $1,437.30 | $1,756.70 |
| Cost of ICC initial | $55,684 | $50,115.60 | $61,252.40 |
| Cost of ICC terminal | $110,033 | $99,029.70 | $121,036.30 |
| Cost of office visit | $74.55 | $67.10 | $82.01 |
| Cost of CIN2 & CIN3 | $1,345 | $1,210.50 | $1,479.50 |
*
The base case value of 5-year ICC survival is 90% for co-testing and 85% for HPV primary; the sensitivity analysis tested the impact of varying 5-year ICC survival for HPV primary to 90%.