TABLE 2.

Plasma and tissue biochemistry

Male mice (n≥5; 6 months of age) were fasted overnight prior to drawing blood, except for leptin when the mice were fasted for 6 h. Lean, fat, and fluid mass was determined using NMR and expressed as % total BW. Values are expressed as mean ± S.E.

	Cc1+/+	Cc1−/−
Body weight (BW) (g)	34.1 ± 1.28	43.3 ± 1.28a
Liver (% BW)	3.91 ± 0.14	4.08 ± 0.23
Visceral adiposity (% BW)	3.23 ± 0.27	4.86 ± 0.17a
Plasma C-peptide (pmol/liter)	174. ± 21.0	432. ± 26.1a
Plasma insulin (pmol/liter)	39.6 ± 4.41	92.5 ± 16.7a
C-peptide/insulin molar ratio	10.2 ± 2.28	4.31 ± 0.63a
Plasma leptin (ng/ml)	12.3 ± 4.52	27.3 ± 4.29a
Skeletal muscle triglyceride (mg of protein/g of tissue)	4.85 ± 0.47	8.89 ± 3.52a

^a p < 0.05 versus Cc1^+/+ mice.