FIGURE 6.

Scabin inhibitor crystal structures. A, Scabin·PJ34 complex structure shown as a ribbon diagram. PJ34 is colored black and represented in stick format. B, Scabin·P6-E complex structure shown as a ribbon diagram. P6-E is colored black and represented in stick format. C, stereo view of active site of Scabin·PJ34 complex structure (magenta) and Scabin-apo structure (green). PJ34 is colored black and represented in stick format. Structural differences among important catalytic residues (Arg⁷⁷ Ser⁷⁸, Lys⁹⁴, Asn¹¹⁰, Ser¹¹⁷, Thr¹¹⁹, Leu¹²⁴, Tyr¹²⁸, Gln¹⁵⁸, and Glu¹⁶⁰) are highlighted. D, stereo view of active site of Scabin·P6-E complex structure (magenta) and Scabin-apo structure (green). P6-E is colored black and represented in stick format. Structural differences among important catalytic residues (Arg⁷⁷ Ser⁷⁸, Lys⁹⁴, Asn¹¹⁰, Ser¹¹⁷, Thr¹¹⁹, Leu¹²⁴, Tyr¹²⁸, Gln¹⁵⁸, and Glu¹⁶⁰) are highlighted.