. 2016 Mar 18;291(21):11268–11284. doi: 10.1074/jbc.M115.703868

TABLE 3.

Impact of Lys-74 and Ile-76 at the FGF14·Nav1.6 complex and the FGF14:FGF14 dimer interface

The number of independent experiments is shown in parentheses. ***, p < 0.001; **, p < 0.01; *, p < 0.05; one-way ANOVA with post hoc Dunn's/Dunnett's multiple comparisons test compared with either FGF14^WT·Nav1.6 or FGF14^WT:FGF14^WT.

Mutations	FGF14^mutant·Nav1.6	FGF14^mutant:FGF14	FGF14^mutant:FGF14^mutant
FGF14^K74A	78 ± 3% (12)*↓	62±%2 (6)**↓	36 ± 2% (6)***↓
FGF14^I76A	91 ± 8% (12)↓	61 ± 8% (6)**↓	82 ± 9% (6)↓
FGF14^K74A/I76A	38 ± 2% (6)***↓	78 ± 17% (3)↓	50 ± 1% (3)***↓