TABLE 4.
Nav1.6-mediated currents in the presence of FGF14 and Val-160 and Tyr-158 mutants
The number of independent experiments is shown in parentheses.
| Condition | Peak density | Activation | Kact | Inactivation | Kinact | τ |
|---|---|---|---|---|---|---|
| pA/pF | mV | mV | mV | mV | ms | |
| GFP | −58.6 ± 13.4 (16) | −20.4 ± 1.6 (12) | 5.3 ± 0.3 (12) | −58.9 ± 0.8(14) | 5.8 ± 0.3 (12) | 1.1 ± 0.1 (14) |
| FGF14-GFP | −9.8 ± 1.5 (14)a | −15.4 ± 1.1 (11)b | 6.3 ± 0.5 (11)c | −54.4 ± 1.4 (10)d | 6.3 ± 0.7(10) | 1.7 ± 0.2 (10)e |
| FGF14V160A-GFP | −44.14 ± 12.4 (10) | −22.4 ± 1.6 (10) | 4.6 ± 0.6 (10) | −58.8 ± 1.3 (10) | 6.4 ± 0.5 (10) | 1.7 ± 0.3 (10)f |
| FGF14Y158A/V160A-GFP | −59.3 ± 14.1 (15) | −21.5 ± 1.6 (15) | 4.6 ± 0.5 (15) | −62.2 ± 1.6 (15) | 7.8 ± 0.9 (15) | 0.8 ± 0.1 (15) |
| FGF14Y158N/V160N-GFP | −58.5 ± 8.5 (11) | −21.5 ± 1.5 (9) | 4.2 ± 0.4 (9) | −62.11 ± 1.3 (9) | 7.4 ± 0.6 (9) | 0.8 ± 0.1 (13) |
a p < 0.001, Kruskal-Wallis, post hoc Dunn's test compared with GFP; data are mean ± S.E.
b p < 0.05, one-way ANOVA, post hoc Dunnett's multiple comparisons test compared with GFP; data are mean ± S.E.
c p < 0.05, one-way ANOVA, post hoc Dunnett's multiple comparisons test compared with GFP; data are mean ± S.E.
d p < 0.001, Kruskal-Wallis, post hoc Dunnett's multiple comparisons test compared with GFP; data are mean ± S.E.
e p < 0.01, one-way ANOVA, post hoc Dunn's multiple comparisons test compared with GFP; data are mean ± S.E.
f p < 0.05, one-way ANOVA, post hoc Dunn's multiple comparisons test compared with GFP; data are mean ± S.E.