TABLE 1.

Model parameter definitions and parameter values in baseline simulations

Parameter	Model baseline value	Definition
kon	105 m−1s−1	Kinetic rate constant for Ab-Ag association
koff	10−4 s−1	Kinetic rate constant for Ab-Ag dissociation
[Ag0]	Calculated based on receptor number/cell	Initial antigen concentration; estimated as solution phase concentration
[Ageff]	Calculated as described in Fig. 2 and “Experimental Procedures”	Effective antigen concentration experienced by antibody bound to cell surface receptor(s)
rIgG	125 Å (28, 29)	Arm to arm distance of an IgG
rcell	8 μm (37)	Radius of an average cell