FIGURE 4.

Chemical modification of M154C channels by MTSET. Shown are representative recordings of experiments conducted with oocytes expressing control (C70L) and M154C mutant channels. Whole-cell currents were elicited by a change in extracellular pH from 8.0 to 5.0 before and after MTSET treatment. Oocytes expressing control and mutant channels were exposed to MTSET (1 mm) at pH 7.0, i.e. channels in the desensitized state (right tracings). Non-treated oocytes served as controls (left tracings).