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. 2016 May 20;23(4):402–409. doi: 10.1097/MOH.0000000000000257

FIGURE 2.

FIGURE 2

Described CARMA1/CARD11 mutations (a) Mutations found in ABC DLBCL and BENTA. An asterisk indicates mutations in DLBCL that were not clearly identified as ABC DLBCL. Amino acid numbers of some CARMA1 mutations [7] have been adjusted to the UniProt sequence. (b) Mutations identified in ATLL and Sézary syndrome; 8% of ATLL cases have a CARMA1 deletion within the linker domain. Mutations that were not functionally tested are indicated in italics. Mutations common to DLBCL and BENTA (a) or common to Sézary syndrome and ATLL (b) are highlighted in blue. ABC, activated B-cell; ATLL, acute T-cell leukemia/lymphoma; BENTA, B-cell expansion with NF-κB and T-cell anergy; CARD, caspase recruitment domain; CC, coiled coil; DLBCL, diffuse large B-cell lymphoma; GUK, guanylate kinase domain; MAGUK, membrane-associated guanylate kinase; PDZ, domain found in the proteins PSD95, Dlg1 and ZO-1; SH3, Src homology-3 domain.