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. Author manuscript; available in PMC: 2016 Jun 9.

Published in final edited form as: Hepatology. 2011 Aug 1;54(4):1282–1292. doi: 10.1002/hep.24492

Table 1. Effect of Bile Acids on Impulse Conduction Characteristics.

Bile Acids		Conduction Velocity, cm/s			Upstroke Velocity, %APA/ms

		Control	Drug	% change	Control	Drug	% change
TC 0.1mmol/L	ACUTE	24.8±3.0	23.8±1.9	-4.0%	36.1±3.7	33.1±1.4	-8.3%
TC 0.1mmol/L	CHRONIC	24.6±4.2	21.6±1.5	-11.8%	43.0±7.6	39.4±5.9	-8.2%
TC 0.3mmol/L	ACUTE	17.2±5.7	15.5±2.9	-9.7%	33.1±1.4	29.2±4.3^*	-11.7%
TC 0.3mmol/L	CHRONIC	17.3±4.3	9.7±2.8^**	-43.8%	42.6±1.5	36.8±5.1^**	-13.4%
TC 0.5mmol/L	ACUTE	17.0±4.3	10.1±1.8^*	-40.6%	47.5±10.8	38.2±2.2^*	-19.3%
TC 0.5mmol/L	CHRONIC	22.1±3.8	10.8±2.9^**	-51.0%	41.3±5.4	30.8±2.5^*	-25.4%
TC 0.5mmol/L + UDCA0.1 μmol/L	ACUTE	17.6±1.3	16.2±2.2	-7.7%	32.5±0.9	33.1±1.9	+1.7%
TC 0.5mmol/L + UDCA0.1 μmol/L	CHRONIC	20.6±4.7	22.1±4.1	+7.1%	43.8±3.1	44.8±2.9	+2.2%

Measured in confluent srands of myofibroblasts-coated cardiomyocytes (n=7 each)

^*

P<0.05 vs. control

^**

P<0.005 vs. control