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. Author manuscript; available in PMC: 2016 Nov 9.
Published in final edited form as: Nature. 2016 May 9;534(7606):277–280. doi: 10.1038/nature17675

Figure 3. Interactions between RelA and the ribosome.

Figure 3

a, Overview (left) and details (right) of the interaction between the ZFD (orange) and RRM (blue) of RelA and the ribosomal ASF (light blue) that spans the intersubunit interface between the P-site (green) and A-site (purple) tRNAs. RelA acts as an additional intersubunit bridge by binding uL16 (cyan) in the large subunit and uS19 (yellow) in the small subunit. b, The α-helix of the ZFD binds in the major groove of the ASF, with the zinc-binding site interacting with the phosphate backbone. c, By binding to uS19, the ZFD occupies the position adopted by the ASF in the rotated ribosome (grey).