Extended Data Figure 3. Examples of RelA density.

a, Density for the interaction between the 3’ CCA of the A/T-tRNA and the TGS domain. b, A modeled tRNA^Ala demonstrates that even the smallest aminoacyl groups would clash with RelA. The sphere size of the atoms of the aminoacyl group corresponds to their Van der Waals radii. c, C74 stacks with His432 and C75 can potentially interact with Arg438 of the TGS domain. d, Density for helix α4 of the TGS domain. e, Density for TGS α3. f, Density for the interaction between the ZFD and uS19, showing distinctive density for two consecutive histidine residues. g, Example of side chain density used for the de novo building of the ZFD.