Table 1.
Demographic and clinical characteristics of the study subjects (mean±S.E.)
| Group/variable | Control (n=41) | Meth (n=25) | HIV (n=34) | HIV+Meth (n=23) | p value ANOVA, T and X2 |
|---|---|---|---|---|---|
| Age (years) | 39.7±2.0 | 39.1±2.0 | 41.8±1.9 | 43.0±1.6 | 0.54 |
| Sex (Male/Female) | 37 (90%) /4 (10%) | 22 (88%) /3 (12%) | 32 (94%) /2 (6%) | 22 (96%) /1 (4%) | 0.73 |
| Ethnicity (Hispanic/Non-Hispanic) | 1 (2%) /40 (98%) | 4 (16%) /21 (84%) | 5 (15%) /29 (85%) | 7 (30%) /16 (70%) | 0.019 |
| Race: | |||||
| American Indian/Native Alaskan | 1 (2%) | 0 (0%) | 1 (3%) | 0 (0%) | 0.032 |
| Asian | 8 (20%) | 6 (24%) | 4 (12%) | 7 (30%) | |
| African American/Black | 1 (2%) | 0 (0%) | 2 (6%) | 3 (13%) | |
| Native Hawaiian/Pacific Islander | 3 (7%) | 5 (20%) | 0 (0%) | 2 (9%) | |
| White | 22 (54%) | 5 (20%) | 18 (53%) | 5 (22%) | |
| Mixed | 6 (15%) | 9 (36%) | 9 (26%) | 6 (26%) | |
| Clinical variables | |||||
| HIV Duration (months) | 199.1±16.8 | 177.1±18.9 | 0.40 | ||
| CD4 (cells/mL) | 433.1±38.1 | 367.0±46.7 | 0.28 | ||
| Nadir CD4 (cells/mL) | 212.9±29.0 | 109.4±23.8 | 0.015 | ||
| HIV Viral Load (VL) (log cp/mL | 2.8±0.3 | 2.6±0.3 | 0.64 | ||
| Subjects with detectable VL | 12 (35%) | 10 (43%) | 0.36 | ||
| HIV Dementia Scale (0–16) | 14.4±0.3 | 13.4±0.7 | 0.15 | ||
| Karnofsky Scale (0–100) | 92.1±1.5 | 90.9±1.4 | 0.59 | ||
| CSF WBCs (cells/mm3) | 4.6±2.4 | 13.3±10.4 | 1.8±0.6 | 31.5±25.6 | 0.24 |
| CSF Glucose (mg/dL) | 60.9±1.0 | 60.9±1.2 | 61.2±3.3 | 62.0±1.9 | 0.99 |
| HIV Medication (yes/no) | 28 (82%) /6 (18%) | 21 (91%) /2 (9%) | 0.57 | ||
| Methamphetamine usage | |||||
| Daily average Meth use (g) | 0.91±0.04 | 0.98±0.03 | 0.78 | ||
| Total lifetime Meth used (g) | 3,771.3±174.9 | 3,464.4±184.1 | 0.81 | ||
| Duration of Meth use (month) | 206.6±4.3 | 195.1±5.4 | 0.73 | ||
| Meth abstinence (month) | 3.5±0.1 | 2.3±0.1 | 0.12 | ||
| Other Drugs used | |||||
| Tobacco Smoking (yes/no) | 30 (73%) /11 (27%) | 19 (76%) /6 (24%) | 24 (71%) /10 (29%) | 12 (52%) /11 (48%) | 0.26 |
| Alcohol (yes/no) | 37 (90%) /4 (10%) | 23 (92%) /2 (8%) | 28 (82%) /6 (18%) | 18 (78%) /5 (22%) | 0.41 |
| Current Marijuana (yes/no) | 10 (24%)/31 (76%) | 4 (16%)/21 (84%) | 10 (29%)/24 (71%) | 6 (26%)/17 (74%) | 0.69 |
Bold numbers indicate statistical significance