Figure 2. The effect of PFT-μ administration on altered mitochondria morphology in peripheral sensory neuron cell bodies.
Representative Electron Microscopy Images from Mitochondria in DRG from Vehicle alone (A) PFT-μ+Vehicle-Treated mice (B), from Paclitaxel-Treated mice (C); and from Paclitaxel+PFT-μ–Treated mice (D). DRG tissues were harvested at week 5 at the moment that paclitaxel-treated mice showed mechanical allodynia. Percentage of atypical mitochondria/mouse (E). n=3 mice/treatment 10–25 mitochondria scored/mouse. Magnification 50,000 x. Statistical analysis using one-way ANOVA revealed a significant difference between groups (p<0.01). Bonferroni post-hoc analysis was used to determine differences between groups. *p<0.05, **p<0.01.