a, Diagram of OPC decorrelation experiment, where wavefront shaping forms a tight focus through pinched, in vivo mouse tissue. b, Focusing light through partially immobilized dorsal skin. Both the speckle autocorrelation (g2(t), black) and OPC focal spot intensity (F(t), red) decay in magnitude over the course of several seconds, with fitted curves. c, In unconstrained skin, decorrelation occurs on a much faster (sub-second) timescale. Figure reproduced with permission from ref. 70, OSA.