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. 2016 Jun 9;11(6):e0157103. doi: 10.1371/journal.pone.0157103

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© 2016 Lin et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — Full genome of acute hepatitis B sequences and other Japanese HBV sequences from GenBank were included for GMRF Skyride analysis. The solid black line indicates the mean effective viral population size, as well, the genetic diversity. The genetic diversity of HBV in Japan has subsided since 1995. This change indicated that the virus was been through a bottleneck and agreed by both Upper and Lower HPD 95% curve.