Table 2. GSTP1 polymorphisms in patients with and without ATDH.
| SNPs | ATDH group N (%) | Non-ATDH group N (%) | OR* (95%CI) | P* |
|---|---|---|---|---|
| Prospective study | ||||
| rs1695 (A>G) | ||||
| Allele | ||||
| G | 7 (11.7) | 102 (19.9) | Reference | |
| A | 53 (88.3) | 410 (80.1) | 3.876 (1.258–11.90) | 0.018 |
| Genotype | ||||
| GG+AG** | 6 (20) | 93 (36.3) | Reference | |
| AA | 24 (80) | 163 (63.7) | 3.68 (1.18–11.36) | 0.025 |
| rs4147581 (G>C) | ||||
| Allele | ||||
| C | 15 (25) | 164 (32.3) | Reference | |
| G | 45 (75) | 344 (67.7) | 1.938 (0.944–3.984) | 0.071 |
| Genotype | ||||
| GC+CC** | 12 (40) | 140 (55.1) | Reference | |
| GG | 18 (60) | 114 (44.9) | 2.578 (1.076–6.173) | 0.034 |
| Retrospective study | ||||
| rs1695 (A>G) | ||||
| Allele | ||||
| G | 24(10.5) | 44(19.3) | Reference | |
| A | 204(89.5) | 184(80.7) | 2.10 (1.17–3.76) | 0.012 |
| Genotype | ||||
| GG+AG** | 24(21.1) | 39(34.2) | Reference | |
| AA | 90(78.9) | 75(65.8) | 2.00 (1.05–3.83) | 0.035 |
| rs4147581 (G>C) | ||||
| Allele | ||||
| C | 55(24.3) | 71(31.1) | Reference | |
| G | 171(75.7) | 157(68.9) | 1.295 (0.831–2.020) | 0.253 |
| Genotype | ||||
| GC+CC** | 48(42.5) | 57(50) | Reference | |
| GG | 65(57.5) | 57(50) | 1.239 (0.704–2.179) | 0.458 |
OR, Odds Ratio; CI, confidence interval
* Adjusted for sex, age, BMI and smoking history with logistic regression.
** Due to the small number of minor allele homozygotes, this genotype was combined with heterozygotes in the analysis.