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. 2016 Jun 9;11(6):e0156731. doi: 10.1371/journal.pone.0156731

Fig 2. BOC/TVR sensitivity of baseline NS3 protease subgenomic HCV replicon libraries.

Fig 2

A) Exemplary representation of IC50 value determination and fold change calculation using titration curves of the wildtype GT1b reference strain (Con1) and the corresponding strain with the low level resistance-conferring RAV V36A. B) Representation of the replication fitness of NS3 subgenomic HCV replicons which is defined as the 72h/4h luciferase ratio relative to the apparent drug sensitivity expressed as fold change of the IC50 value. (c) Sensitivity of single phenotypes in correlation with RAVs and outcome of infection. (d) Association of phenotype sensitivity with RAVs. (e) Phenotype sensitivity after subgrouping of virologic failure samples by relapse (Rel.), breakthrough (BT) and non-response (NR) in comparison to SVR. (f) Subgrouping of NS3 phenotypes according to the viral subtype.