Table 1. The pharmacokinetic parameters of geniposide, magnolflorine, baicalin, berberine, oroxylin A-7-O-glucuronide, wogonoside, wogonin and oroxylin A in normal and inflamed rats.
| PK parameters | Group | baicalin | oroxylin A-7-O-glucuronide | wogonoside | geniposide | magnolflorine | berberine | wogonin | oroxylin A |
|---|---|---|---|---|---|---|---|---|---|
| Dose (g/kg) | B/M | 0.1246 | 0.0236 | 0.0910 | 0.0881 | 0.0024 | 0.0296 | 0.0063 | 0.0025 |
| HLλz (h) | B | 1.8±0.4 | 3.2±0.9 | 3.0±1.0 | 0.6±0.3 | 1.6±0.4 | 6.3±3.5 | 3.5±1.3 | 1.7±0.9 |
| M | 4.7±1.1 | 20.1±6.1 | 12.2±5.9 | 1.6±0.7 | 4.3±2.2 | 9.1±2.5 | 7.1±2.7 | 16.3±8.8 | |
| Tmax1 (h) | B | 0.09±0.03 | 0.09±0.03 | 0.11±0.04 | 0.7±0.3 | 0.6±0.2 | 0.6±0.4 | 0.09±0.03 | 0.08±0.0 |
| M | 0.1±0.04 | 0.09±0.03 | 0.16±0.08 | 0.8±0.3 | 0.6±0.3 | 1.0±0.6 | 0.08±0.0 | 0.08±0.0 | |
| Tmax2 (h) | B | 4.3±0.8 | 4.0±0.0 | 4.3±0.8 | - | - | 8.0±2.2 | 4.0±0.0 | 4.0±0.0 |
| M | 9.3±2.1 | 9.6±2.2 | 8.7±3.0 | - | - | 10.8±2.7 | 7.3±2.7 | 7.0±3.0 | |
| Cmax1 (ng/ml) | B | 1828.8±737.4 | 106.9±43.8 | 492.9±152.9 | 171.6±70.6 | 6.5±1.1 | 0.4±0.1 | 2.2±1.2 | 1.5±0.6 |
| M | 2420.9±922.5 | 108.7±47.6 | 571.9±183.4 | 223.2±43.7 | 6.0±1.7 | 0.5±0.2 | 3.3±0.7 | 2.5±1.1 | |
| Cmax2 (ng/ml) | B | 1580.1±202.4 | 85.8±40.3 | 517.7±173.8 | - | - | 0.1±0.03 | 1.6±0.7 | 0.4±0.1 |
| M | 1000.4±298.1 | 65.5±18.2 | 323.9±52.5 | - | - | 0.3±0.3 | 4.3±1.8 | 2.3±0.8 | |
| AUClast (h*ng/ml) | B | 7881.1±774.7 | 440.7±106.9 | 3302.3±975.1 | 216.8±86.2 | 16.0±2.0 | 1.3±0.5 | 7.2±2.6 | 2.3±0.5 |
| M | 15737.7±9300.3 | 1209.8±606.4 | 6870.4±1786.5 | 637.6±323.1 | 24.9±14.6 | 2.7±0.8 | 38.7±8.1 | 21.1±4.1 | |
| AUCinf (h*ng/ml) | B | 8129.0±906.2 | 486.8±96.9 | 3615.4±872.3 | 239.9±82.1 | 17.0±2.0 | 1.8±0.6 | 7.4±2.6 | 2.4±0.5 |
| M | 16842.2±9089.7 | 2157.4±785.0 | 8380.9±1944.5 | 695.7±362.8 | 29.3±13.8 | 3.4±0.7 | 39.2±8.0 | 24.6±6.1 | |
| AUC%Extrap (%) | B | 2.9±2.3 | 10.3±6.8 | 9.6±6.6 | 11.5±1.5 | 6.2±2.4 | 25.9±15.5 | 2.7±2.3 | 5.3±3.4 |
| M | 2.7±0.5 | 46.2±12.3 | 17.3±13.8 | 8.9±2.9 | 17.6±8.0 | 10.7±7.0 | 1.3±0.7 | 13.4±8.6 | |
| Vz/F (L/kg) | B | 39.6±7.1 | 247.8±140.4 | 118.7±58.0 | 235.1±94.2 | 339.5±97.3 | 145349.8±40480.7 | 4013.3±1353.8 | 2496.7±1078.9 |
| M | 58.8±25.2 | 322.4±22.0 | 188.6±72.3 | 372.2±86.7 | 607.8±396.5 | 118054.1±38377.6 | 1706.5±666.9 | 2822.5±507.0 | |
| CL/F (L/h/kg) | B | 15.5±1.7 | 50.7±13.5 | 26.5±7.0 | 411.5±160.9 | 142.6±15.9 | 18437.4±7250.1 | 763.9±114.0 | 1089.6±241.5 |
| M | 8.7±3.2 | 12.1±4.2 | 11.4±2.7 | 225.4±108.6 | 923.7±274.2 | 9105.5±2316.3 | 164.6±28.8 | 107.4±27.0 | |
| AUMClast (h*h*ng/ml) | B | 34124.1±4967.9 | 1935.2±487.3 | 15357.0±3545.6 | 192.5±74.8 | 29.5±5.8 | 8.9±8.6 | 31.8±14.3 | 7.1±2.7 |
| M | 175077.1±103375.1 | 18194.0±6706.5 | 92756.1±44786.8 | 1231.9±677.2 | 97.9±55.4 | 22.6±8.6 | 442.5±232.9 | 365.4±192.9 | |
| MRTlast (h) | B | 4.3±0.3 | 4.4±0.5 | 4.7±0.5 | 0.9±0.1 | 1.8±0.1 | 5.7±3.5 | 4.3±0.8 | 3.0±0.6 |
| M | 10.1±2.3 | 12.5±2.3 | 12.9±3.0 | 1.9±0.8 | 4.1±1.9 | 8.4±3.1 | 11.0±3.5 | 16.5±6.2 |
B, normal group with HLJDD; M, inflamed group with HLJDD