Table 3. Associations Between Serum Potassium and Incident Diabetes, by Ethnicity (N = 5415).
Hazard ratio (95% CI) | |||||
---|---|---|---|---|---|
Serum K (mmol/L) | Number at risk | Number of events | Unadjusted incidence ratio (per 1000 pys) | Model 1 | Model 2 |
All participants | 5415 | 1281 | 30.8 | ||
< 4.0 | 1767 | 208 | 35.0 | 1.23 (1.04, 1.47) | 0.96 (0.75, 1.24) |
4.0–4.49 | 804 | 662 | 29.8 | 0.99 (0.87, 1.12) | 1.05 (0.89, 1.23) |
≥ 4.5 | 2844 | 411 | 30.5 | 1.0 (Ref.) | 1.0 (Ref.) |
per 0.5 lower | 1.11 (1.02, 1.20) | 1.01 (0.91, 1.12) | |||
p-value | 0.02 | 0.86 | |||
White | 2281 | 477 | 26.0 | ||
< 4.0 | 238 | 51 | 28.6 | 1.22 (0.89, 1.68) | 0.98 (0.66, 1.45) |
4.0–4.49 | 1117 | 235 | 25.5 | 1.02 (0.84, 1.23) | 1.13 (0.91, 1.42) |
≥ 4.5 | 926 | 191 | 25.9 | 1.0 (Ref.) | 1.0 (Ref.) |
per 0.5 lower | 1.14 (0.99, 1.30) | 1.05 (0.91, 1.22) | |||
p-value | 0.06 | 0.49 | |||
Chinese-American | 679 | 175 | 34.0 | ||
< 4.0 | 160 | 42 | 34.4 | 0.85 (0.51, 1.40) | 0.47 (0.21, 1.08) |
4.0–4.49 | 435 | 107 | 32.2 | 0.75 (0.48, 1.18) | 0.50 (0.26, 0.97) |
≥ 4.5 | 84 | 26 | 43.0 | 1.0 (Ref.) | 1.0 (Ref.) |
per 0.5 lower | 0.96 (0.74, 1.25) | 0.85 (0.52, 1.39) | |||
p-value | 0.77 | 0.52 | |||
African-American | 1345 | 290 | 29.2 | ||
< 4.0 | 270 | 63 | 31.9 | 1.17 (0.84, 1.63) | 0.77 (0.46, 1.30) |
4.0–4.49 | 707 | 148 | 27.9 | 0.96 (0.72, 1.26) | 0.95 (0.64, 1.40) |
≥ 4.5 | 368 | 79 | 29.8 | 1.0 (Ref.) | 1.0 (Ref.) |
per 0.5 lower | 1.05 (0.89, 1.23) | 0.88 (0.70, 1.11) | |||
p-value | 0.56 | 0.27 | |||
Hispanic | 1110 | 339 | 41.6 | ||
< 4.0 | 136 | 52 | 54.0 | 1.51 (1.09, 2.08) | 1.27 (0.81, 1.98) |
4.0–4.49 | 585 | 172 | 39.4 | 1.02 (0.80, 1.29) | 1.08 (0.79, 1.49) |
≥ 4.5 | 389 | 115 | 40.9 | 1.0 (Ref.) | 1.0 (Ref.) |
per 0.5 lower | 1.19 (1.00, 1.41) | 1.08 (0.88, 1.33) | |||
p-value | 0.04 | 0.46 |
Model 1: adjusted for age (continuous), sex, race, and study site.
Model 2: M1 + waist circumference (continuous), BMI (continuous), smoking, family history of diabetes, education, income, alcohol use, physical activity, systolic blood pressure, antihypertensive medication use and use of other medications listed in Table 1.
Significant associations in bold. Race*serum potassium, P = 0.25