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. 2016 Jun 9;11(6):e0156200. doi: 10.1371/journal.pone.0156200

Fig 2. Peg-IFN-α altered peripheral transitional and naive B-cell subset distribution.

Fig 2

Evolution of B-cell subsets was evaluated in patients with CHB before and at different time points during the treatment with nucleos(t)ide analog alone (open circles, n = 11–14) or together with Peg-IFN-α (black circles, n = 8–9). (A) Absolute numbers of transitional B-cell subsets. (B) Absolute numbers of naive B-cell subsets. (C) Representative dot plots of the frequency of transitional and naive B cells from patients treated with nucleos(t)ide analogue alone (upper panel) or together with Peg-IFN-α (lower panel) before and after 24 weeks of treatment. Dot plots are gated on CD19+IgD+CD27- cells. The gray area represents the period of Peg-IFN-α administration. Bars represent median. P values were calculated using the Wilcoxon test (straight lines) or the Mann-Whitney test (dashed lines). * p<0.05, ** p<0.01, *** p<0.001.