Table 3.

Association between ANGPTL4 E40K or Other Inactivating Mutations and Coronary Artery Disease.^*

Variants	Allele Frequency		Odds Ratio (95% CI)	P Value
	CAD Cases	CAD Controls
E40K mutation in 1661 heterozygotes and 17 homozygotes	1.71	2.10	0.81 (0.70–0.92)	0.002
Heterozygous inactivating mutations in 75 participants	0.06	0.10	0.56 (0.32–1.00)	0.05

^*Odds ratios were calculated by means of Firth’s penalized likelihood method of logistic regression after adjustment for age, age squared, sex, and four principal components of ancestry. An odds ratio of less than 1.00 indicates protection against coronary artery disease. P values were calculated by means of a mixed-linear-model association method after adjustment for age, age squared, sex, and genetic relatedness. CAD denotes coronary artery disease, and CI confidence interval.