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. 2015 Nov 17;37(22):1753–1761. doi: 10.1093/eurheartj/ehv564

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© The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Nox4^−/− mice show altered flow-mediated dilation in vivo. (A) Representative optical coherence tomography images of Arteria saphena and evaluation of images of 26-week-old (A) wild-type, (B) Ldlr^−/−, and (C) Nox4^−/− mice under control conditions (basal), flow-mediated dilation and after application of sodium nitroprusside. (D) Representative optical coherence tomography scan of the Arteria saphena of 26-week-old wild-type, Ldlr^−/−, and Nox4^−/− mice showing the process of flow-mediated dilation during 10 min after occlusion (n = 10).