TABLE V.

Factors associated with chemotherapy discontinuation because of toxicity

Factor	Comparator	Analysis
		Univariable			Multivariable
		Estimate	95% CL	p Value	Estimate	95% CL	p Value
Age ≥ 85 years	<85 Years	1.83	0.70, 4.79	0.22	4.12	0.91, 18.75	0.07
Male sex	Female	1.66	0.68, 4.00	0.26	2.38	0.75, 7.57	0.14
Hemoglobin < 100 g/L	≥100 g/L	0.87	0.34, 2.20	0.77	2.11	0.09, 47.32	0.64
White blood cells > 11×109/L	≤11×109/L	0.70	0.29, 1.65	0.41	0.53	0.03, 10.41	0.68
eGFR < 60 mL/min/1.73 m2	≥60 mL/min/1.73 m2	0.42	0.17, 1.01	0.05	0.36	0.11, 1.13	0.08
Palliative therapy	Others	1.34	0.14, 13.29	0.80	0.91	0.11, 7.51	0.93
Modified CCI score ≥ 2	<2	0.34	0.16, 0.97	0.04	0.51	0.20, 1.32	0.17
≥6 Medications	0–5 Medications	1.31	0.51, 3.38	0.58	2.13	0.77, 5.86	0.15
Adjusted first dose	Unadjusted	0.65	0.23, 1.78	0.40	0.72	0.20, 2.60	0.62
Second-line or greater chemotherapy	First-line	1.38	0.58, 3.33	0.47	1.51	0.52, 4.39	0.45

CL = confidence limits; eGFR = estimated glomerular filtration rate; CCI = Charlson comorbidity index.