TABLE V.
Univariate analysis of factors that might affect overall survival (OS)
| Factor | 1-Year OS (%) | p Value |
|---|---|---|
| Age group | ||
| ≤5 Years | 75 | 0.37 |
| 6–11 Years | 55 | |
| 12–18 Years | 58.8 | |
| Sex | ||
| Girls | 50 | 0.17 |
| Boys | 71.8 | HR: 1.71 95% CI: 0.799 to 3.645 |
| Pathologic type | ||
| Rhabdomyosarcoma | 70.7 | 0.12 |
| Neuroblastoma | 53.8 | |
| Wilms tumour | 75 | |
| Brain tumour | 37.5 | |
| Primitive neuroectodermal tumour | 62.5 | |
| Other | 63.6 | |
| Progression or relapse pattern | ||
| Progression | 20.5 | 0.0003 |
| Isolated local recurrence | 83.3 | |
| Isolated distant metastasis | 64.2 | |
| Combined relapse | 68.8 | |
| Response to treatment | ||
| Partial response | 81.8 | <0.0001 |
| Stable disease | 70.4 | |
| Progressive disease | 16.7 | |
| Presence of toxicity | ||
| Yes | 51 | 0.056 |
| No | 82.6 | HR:0.48 95% CI: 0.23 to 1.02 |
| Timing of relapse from initial Tx | ||
| Early (<18 months) | 48.4 | 0.0002 |
| Late (≥18 months) | 84 |
HR = hazard ratio; CI = confidence interval; Tx = treatment.